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It belongs to a class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists , which work by mimicking the action of a naturally occurring hormone that regulates blood glucose levels and appetite

doi:10.2337/db06-S020 219

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If tirzepatide gets approved for additional indications like NASH, sleep apnea, CKD, heart failure, pre-diabetes, etc., it could significantly increase the market opportunity for Eli Lilly

Rationale for combining GLP-1RAs and SGLT2is Mechanistic perspective GLP-1RAs and SGLT2is affect glucose metabolism differently (Fig